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2,3-Dehydro-2-deoxy-N-acetylneuraminic acid

Selected Variant

HY-125798-01

Size: 1 mg

N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity[1][2].

Product Specifications

CAS Number

24967-27-9

Product Name Alternative

Neu5Ac2en; DANA

UNSPSC

12352005

Target

Influenza Virus

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/2-3-dehydro-2-deoxy-n-acetylneuraminic-acid.html

Purity

99.0

Solubility

DMSO : 1 mg/mL (ultrasonic; warming) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

OC[C@@H](O)[C@H]([C@@]1([H])[C@@H]([C@H](C=C(O1)C(O)=O)O)NC(C)=O)O

Molecular Formula

C11H17NO8

Molecular Weight

291.25

References & Citations

[1]Magesh S, et al. Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: selective inhibitors of lysosomal sialidase (NEU1) . Bioorg Med Chem Lett. 2008;18 (2) :532-537.|[2]Xiao A, et al. Sialidase-catalyzed one-pot multienzyme (OPME) synthesis of sialidase transition-state analogue inhibitors. ACS Catal. 2018;8 (1) :43-47.|[3]Karhadkar TR, et al. Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model. Sci Rep. 2017;7 (1) :15069. Published 2017 Nov 8.|[4]Minami A, et al. The sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid is a glucose-dependent potentiator of insulin secretion. Sci Rep. 2020;10 (1) :5198. Published 2020 Mar 23.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Price

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