2,3-Dehydro-2-deoxy-N-acetylneuraminic acid
Product Specifications
Product Name Alternative
Neu5Ac2en; DANA
UNSPSC Description
N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid (Neu5Ac2en) is a potent neuraminidase (sialidase) inhibitor. N-acetyl-2,3-dehydro-2-Deoxyneuraminic Acid shows inhibitory activities against human neuraminidase enzymes with IC50s of 143, 43, 61, and 74 μM for NEU1, NEU2, NEU3, and NEU4, respectively. Anti-influenza virus activity[1][2].
Target Antigen
Influenza Virus
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/2-3-dehydro-2-deoxy-n-acetylneuraminic-acid.html
Purity
99.0
Solubility
DMSO : 1 mg/mL (ultrasonic;warming)|H2O : 33.33 mg/mL (ultrasonic)
Smiles
OC[C@@H](O)[C@H]([C@@]1([H])[C@@H]([C@H](C=C(O1)C(O)=O)O)NC(C)=O)O
Molecular Weight
291.25
References & Citations
[1]Magesh S, et al. Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: selective inhibitors of lysosomal sialidase (NEU1). Bioorg Med Chem Lett. 2008;18(2):532-537.|[2]Xiao A, et al. Sialidase-catalyzed one-pot multienzyme (OPME) synthesis of sialidase transition-state analogue inhibitors. ACS Catal. 2018;8(1):43-47.|[3]Karhadkar TR, et al. Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model. Sci Rep. 2017;7(1):15069. Published 2017 Nov 8.|[4]Minami A, et al. The sialidase inhibitor 2,3-dehydro-2-deoxy-N-acetylneuraminic acid is a glucose-dependent potentiator of insulin secretion. Sci Rep. 2020;10(1):5198. Published 2020 Mar 23.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-125798/2-3-Dehydro-2-deoxy-N-acetylneuraminic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-125798/2-3-Dehydro-2-deoxy-N-acetylneuraminic-acid-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
24967-27-9
Available Sizes
Curated Selection
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