Pipernonaline
Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca (2+), and mitochondrial membrane depolarization[1].
Product Specifications
CAS Number
88660-10-0
UNSPSC
12352005
Hazard Statement
H302-H413
Target
Apoptosis; Caspase
Type
Natural Products
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pipernonaline.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCCCC1)/C=C/CCCC/C=C/C2=CC=C(OCO3)C3=C2
Molecular Formula
C21H27NO3
Molecular Weight
341.44
Precautions
P264-P270-P273-P330-P501
References & Citations
[1]Lee W, et al. Pipernonaline from Piper longum Linn. induces ROS-mediated apoptosis in human prostate cancer PC-3 cells. Biochem Biophys Res Commun. 2013 Jan 4;430 (1) :406-12..
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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