Pipernonaline

Pipernonaline is a piperine derivative with antiprostate cancer activity. Pipernonaline inhibits the proliferation of androgen-dependent/independent LNCaP/PC-3 prostate cells. Pipernonaline activates caspase-3 and promotes procaspase-3/PARP cleavage. Pipernonaline also mediates reactive oxygen species (ROS) production, increased intracellular Ca (2+), and mitochondrial membrane depolarization[1].

Product Specifications

CAS Number

[88660-10-0]

UNSPSC

12352005

Hazard Statement

H302-H413

Target

Apoptosis; Caspase

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pipernonaline.html

Solubility

10 mM in DMSO

Smiles

O=C(N1CCCCC1)/C=C/CCCC/C=C/C2=CC=C(OCO3)C3=C2

Molecular Formula

C21H27NO3

Molecular Weight

341.44

Precautions

P264-P270-P273-P330-P501

References & Citations

[1]Lee W, et al. Pipernonaline from Piper longum Linn. induces ROS-mediated apoptosis in human prostate cancer PC-3 cells. Biochem Biophys Res Commun. 2013 Jan 4;430 (1) :406-12..