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BIM-23027

BIM-23027 is a selective agonist of sst2 receptor (EC50=0.32 nM), with similar effect to somatostatin (SRIF), a cyclic tetradecapeptide. BIM-23027 stimulates dopamine release, which is mediated by a Glu-dependent mechanism[1][2].

Product Specifications

CAS Number

78981-49-4

UNSPSC

12352209

Target

Dopamine Receptor; Somatostatin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bim-23027.html

Purity

99.76

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](NC([C@@H](N(C([C@@H](NC([C@](NC([C@@H](NC1=O)CCCCN)=O)([H])[C@H](O)C)=O)CC2=CC=CC=C2)=O)C)C)=O)CC3=CC=CC=C3)N[C@@H]1CC4=CNC5=CC=CC=C45

Molecular Formula

C43H54N8O7

Molecular Weight

794.94

References & Citations

[1]Hathway GJ, et al. Evidence that somatostatin sst2 receptors mediate striatal dopamine release. Br J Pharmacol. 1999 Nov;128 (6) :1346-52. |[2]McKeen ES, et al. Somatostatin receptors mediating inhibition of basal and stimulated electrogenic ion transport in rat isolated distal colonic mucosa. Naunyn Schmiedebergs Arch Pharmacol. 1995 Oct;352 (4) :402-11.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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