RARα antagonist 1
RARα antagonist 1 (compound 21) is an orally active and selective retinoic acid receptor α (RARα) antagonist, with the IC50 of 4.6nM[1].
Product Specifications
UNSPSC
12352005
Target
RAR/RXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/rarα-antagonist-1.html
Purity
99.07
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC(C1=CC=C(NC(C(C=C2)=CC3=C2OC(C)(C)C=C3C4=CC=C(C)C=C4)=O)C=C1)=O
Molecular Formula
C26H23NO4
Molecular Weight
413.47
References & Citations
[1]Al Noman MA, et al. Strategies for developing retinoic acid receptor alpha-selective antagonists as novel agents for male contraception [published online ahead of print, 2023 Sep 25]. Eur J Med Chem. 2023;261:115821.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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