ZK159222

ZK159222, a 25-carboxylic ester analogue of 1α,25- (OH) 2D3, is a potent 1α,25- (OH) 2D3 receptor (VDR) antagonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. ZK159222 has a partial agonistic character[1].

Product Specifications

CAS Number

[156965-15-0]

UNSPSC

12352211

Target

VD/VDR

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/zk159222.html

Purity

99.23

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1([C@H](O)/C=C/[C@H]([C@H]2CC[C@@]3([H])/C(CCC[C@]23C)=C/C=C4C([C@@H](O)C[C@H](O)C\4)=C)C)CC1)OCCCC

Molecular Formula

C32H48O5

Molecular Weight

512.72

References & Citations

[1]Herdick M, et al. Antagonistic action of a 25-carboxylic ester analogue of 1alpha, 25-dihydroxyvitamin D3 is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. J Biol Chem. 2000 Jun 2;275 (22) :16506-12.