Sincalide (ammonium)

Sincalide ammonium (Cholecystokinin octapeptide ammonium, CCK-8 ammonium) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK. CCK‐8 can promote gallbladder contraction by injection and helps diagnose gallbladder and pancreas disorders. Sincalide ammonium can increase bile secretion, cause the gallbladder to contract and relax the sphincter of Oddi, resulting in bile drainage into the duodenum. Sincalide ammonium is a major bioactive segment of CCK that retains most of the biological activities of CCK[1][2][3].

Product Specifications

CAS Number

[70706-98-8]

Product Name Alternative

Cholecystokinin octapeptide (ammonium) ; CCK-8 (ammonium) ; SQ19844 (ammonium)

UNSPSC

12352209

Target

Akt; Apoptosis; Cholecystokinin Receptor; PI3K

Type

Peptides

Related Pathways

Apoptosis; GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/sincalide-ammonium.html

Purity

99.90

Solubility

H2O : 33.33 mg/mL (ultrasonic)

Smiles

NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CNC2=C1C=CC=C2)NC(CNC([C@@H](NC([C@H](CC3=CC=C(C=C3)OS(=O)(O)=O)NC([C@H](CC(O)=O)N)=O)=O)CCSC)=O)=O)=O)CCSC)=O)CC(O)=O)=O)CC4=CC=CC=C4)=O.N

Molecular Formula

C49H65N11O16S3

Molecular Weight

1160.30

References & Citations

[1]Maher KA. Kinevac (sincalide for injection) /Squibb Diagnostics. Gastroenterol Nurs. 1991 Oct;14 (2) :98-100.|[2]Ziessman HA. Sincalide: A Review of Clinical Utility, Proper Infusion Methodology, and Alternative Cholecystogogues. J Nucl Med Technol. 2019 Sep;47 (3) :210-212.|[3]Can Wang, et al. Protective effect of cholecystokinin octapeptide on angiotensin II-induced apoptosis in H9c2 cardiomyoblast cells. J Cell Biochem. 2020 Jul;121 (7) :3560-3569.|[4]Can Wang, et al. Cholecystokinin octapeptide reduces myocardial fibrosis and improves cardiac remodeling in post myocardial infarction rats. Int J Biochem Cell Biol. 2020 Aug;125:105793.