LH1306
LH1306 is a C2-symmetric inhibitor of PD-1/PD-L1 protein-protein interaction (PPI), with an IC50 value of 25 nM. LH1306 can be used in anti-tumor research[1].
Product Specifications
CAS Number
2182653-84-3
UNSPSC
12352005
Target
PD-1/PD-L1
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/lh1306.html
Solubility
10 mM in DMSO
Smiles
CC(NCCNCC(C(OC)=N1)=CC=C1OCC2=CC=CC(C3=CC=CC(COC4=CC=C(C(OC)=N4)CNCCNC(C)=O)=C3C)=C2C)=O
Molecular Formula
C38H48N6O6
Molecular Weight
684.82
References & Citations
[1]Basu S, et al. Design, synthesis, evaluation, and structural studies of C 2-symmetric small molecule inhibitors of programmed cell death-1/programmed death-ligand 1 protein–protein interaction[J]. Journal of Medicinal Chemistry, 2019, 62 (15) : 7250-7263.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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