ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid
Product Specifications
UNSPSC Description
ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid is an anti-melanin synthesis tyrosinase inhibitor, which can be isolated from Pteris fern. ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid regulates the melanogenesis transcription factor microphthalmia-associated transcription factor (MITF). The 11α-OH, 15-oxo and 16-en moieties of ent-11α-Hydroxy-15-oxokaur-16-en-19-oic acid are key fragments that inhibit melanin synthesis. The 19-COOH moiety has been implicated in the inhibition of cytotoxicity associated with 11α-OH KA and related compounds[1].
Target Antigen
Tyrosinase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ent-11α-hydroxy-15-oxokaur-16-en-19-oic-acid.html
Solubility
10 mM in DMSO
Smiles
O=C1C([C@@]2([H])C[C@]13[C@]([C@@H](O)C2)([H])[C@]4([C@]([C@@](C)(CCC4)C(O)=O)([H])CC3)C)=C
Molecular Weight
332.43
References & Citations
[1]Kuroi A, et al. The Importance of 11伪-OH, 15-oxo, and 16-en Moieties of 11伪-Hydroxy-15-oxo-kaur-16-en-19-oic Acid in Its Inhibitory Activity on Melanogenesis. Skin Pharmacol Physiol. 2017;30(4):205-215.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N3810/ent-11α-Hydroxy-15-oxokaur-16-en-19-oic-acid-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N3810/
Clinical Information
No Development Reported
CAS Number
57719-81-0
Available Sizes
Curated Selection
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