LC3-mHTT-IN-AN2
Product Specifications
UNSPSC Description
LC3-mHTT-IN-AN2 (Compound AN2) is a mHTT-LC3 linker compound, which interacts with both mutant huntingtin protein (mHTT) and LC3B but not with wtHTT or irrelevant control proteins. LC3-mHTT-IN-AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons[1].
Target Antigen
Atg8/LC3; ATTECs; Autophagy
Type
Natural Products
Related Pathways
Autophagy;PROTAC
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lc3-mhtt-in-2.html
Purity
98.12
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
OC1=C2C(OC(C=C2C3=CC=CC=C3)=O)=CC(O)=C1
Molecular Weight
254.24
References & Citations
[1]Li Z, et al. Allele-selective lowering of mutant HTT protein by HTT-LC3 linker compounds. Nature. 2019 Oct 30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130259/LC3-mHTT-IN-AN2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130259/LC3-mHTT-IN-AN2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
7758-73-8
Available Sizes
Curated Selection
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