TAK1-IN-5
TAK1-IN-5 (Compound 26) is an inhibitor of the transforming growth factor-β activated kinase (TAK1) with an IC50 value of 55 nM. TAK1-IN-5 can inhibit the growth of MPC-11 and H929 cells with a GI50 lower than 30 nM. TAK1-IN-5 can be used in the study of multiple myeloma [1].
Product Specifications
UNSPSC
12352005
Target
MAP3K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tak1-in-5.html
Solubility
10 mM in DMSO
Smiles
CC1CN(CC(O1)C)C2=NN3C(C4=CC5=C(NN=C5C6CC6)C=C4)=CN=C3C=C2
Molecular Formula
C22H24N6O
Molecular Weight
388.47
References & Citations
[1]Akwata D, et al. Discovery of imidazo[1,2-b]pyridazine-containing TAK1 kinase inhibitors with excellent activities against multiple myeloma. RSC Med Chem. 2023 Nov 28;15 (1) :178-192.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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