aStAx-35R (TFA)
Product Specifications
UNSPSC Description
aStAx-35R TFA, a stapled peptide, antagonizes nuclear form of β-catenin and inhibits Wnt signaling. aStAx-35R TFA inhibits competitively the binding of β-catenin to TCF4. aStAx-35R TFA selectively induces growth inhibition of Wnt-dependent cancer cells[1].
Target Antigen
Wnt; β-catenin
Type
Peptides
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/astax-35r-tfa.html
Purity
99.18
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(C(F)(F)F)=O.O=C([C@H](CCCNC(N)=N)NC(C)=O)N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N3CCC[C@H]3C(N[C@@H](CCCNC(N)=N)C(N[C@](C)(C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(C)C)C(N[C@H]4CC(O)=O)=O)=O)=O)CCC/C=C/CCC[C@@](C)(C(N[C@@H](CC5=CN=CN5)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC6=CNC7=C6C=CC=C7)C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)=O)=O)=O)=O)=O)=O)NC4=O)=O)=O)=O)=O.[x]
Molecular Weight
2392.86 (free base)
References & Citations
[1]Grossmann TN, et al. Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin. Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):17942-7.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P10392B/aStAx-35R-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P10392B/aStAx-35R-TFA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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