Desethyl chloroquine-d5

Desethyl chloroquine-d5 is deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs) . Desethyl chloroquine possesses antiplasmodic activity[1][2].

Product Specifications

CAS Number

[1261392-69-1]

UNSPSC

12352005

Target

Autophagy; Isotope-Labeled Compounds; Parasite; Toll-like Receptor (TLR)

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Autophagy; Immunology/Inflammation; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Solubility

10 mM in DMSO

Smiles

CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCNC([2H])([2H])C([2H])([2H])[2H]

Molecular Formula

C16H17D5ClN3

Molecular Weight

296.85

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Ajayi FO, et al. Comparison of the partitioning in vitro of chloroquine and its desethyl metabolites between the erythrocytes and plasma of healthy subjects and those with falciparum malaria. Afr J Med Med Sci. 1989 Jun;18 (2) :95-100.|[3]Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193 (12) :6135-43.|[4]Vodicka P, et al. Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice. J Huntingtons Dis. 2014;3 (2) :159-74.