LDCA

LDCA is a dual-hit metabolic modulator and inhibits LDH-A enzyme activity to stimulate apoptosis in the malignant population. LDCA can be used for the research of oncogenic progression[1].

Product Specifications

CAS Number

[349106-80-5]

UNSPSC

12352005

Hazard Statement

H302-H314

Target

Apoptosis; Lactate Dehydrogenase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ldca.html

Purity

99.18

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=C(Cl)C=C(NC(C(Cl)Cl)=O)C=C1

Molecular Formula

C8H5Cl3FNO

Molecular Weight

256.49

Precautions

P260-P264-P270-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P330-P363-P405-P501

References & Citations

[1]Saha, Suchandrima, et al. The dual-hit metabolic modulator LDCA synergistically potentiates doxorubicin to selectively combat cancer-associated hallmarks. RSC Advances, 7 (84), 53322–53333. doi:10.1039/c7ra08625c.