H-Tyr-Phe-OH

H-Tyr-Phe-OH (L-Tyrosyl-L-phenylalanine) is an orally active inhibitor of Angiotensin converting enzyme (ACE), with an inhibiton rate of 48% at 50 μM. H-Tyr-Phe-OH can be used as an biomarker for differentiating benign thyroid nodules (BTN) from thyroid cancer (TC) . H-Tyr-Phe-OH exhibits xanthine oxidase inhibition (uric acid lowering) activity and serves as regulator in IL-8 production in neutrophil-like cells[1][2][3][4].

Product Specifications

CAS Number

[17355-11-2]

Product Name Alternative

L-Tyrosyl-L-phenylalanine

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin-converting Enzyme (ACE) ; Xanthine Oxidase

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/h-tyr-phe-oh.html

Purity

99.46

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

OC([C@H](CC1=CC=CC=C1)NC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O

Molecular Formula

C18H20N2O4

Molecular Weight

328.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Zhu Wei, et al. Biomarker containing keratin type II cytoskeleton 1b for differentiating benign thyroid nodules and thyroid cancer: China, CN114264828A[P]. 2022-04-01.|[2]Enari Hiroyuki, et al. Angiotensin converting enzyme (ACE) -inhibiting peptides, ACE inhibitors containing the peptides, their uses, and manufacture of the peptides from shark cartilage: Japan, JP2005154326A[P]. 2005-06-16.|[3]Mao Xiangchao, et al. Method for preparing cod fish peptide with xanthine oxidase inhibitory activity: China, CN113005166A[P]. 2021-06-22.|[4]Hsueh PC, et al. Metabolomic profiling of parapneumonic effusion reveals a regulatory role of dipeptides in interleukin-8 production in neutrophil-like cells. Anal Chim Acta. 2020 Sep 1;1128:238-250.