5'-Amino-5'-deoxyadenosine
5'-Amino-5'-deoxyadenosine (NH2dAdo; Nsc 238990) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
[14365-44-7]
Product Name Alternative
NH2dAdo; Nsc 238990
UNSPSC
12352005
Hazard Statement
H302
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-amino-5-deoxyadenosine.html
Purity
96.40
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@@H](CN)O[C@@H](N2C(N=CN=C3N)=C3N=C2)[C@@H]1O
Molecular Formula
C10H14N6O3
Molecular Weight
266.26
Precautions
H302
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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