C-Met degrader-1
C-Met degrader-1 (Compound H11) is an orally active c-Met degrader (through the ubiquitin proteasome system) . c-Met degrader-1 has anti-hepatocellular carcinoma activity (HCC) and inhibits tumor growth in MHCC97H xenografts. c-Met degrader-1 inhibits HCC cell growth, arrests cell cycle, and induces apoptosis. c-Met degrader-1 may overcome resistance to type Ib inhibitors[1].
Product Specifications
UNSPSC
12352211
Target
Apoptosis; c-Met/HGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-met-degrader-1.html
Smiles
O=C1C=CC(C2=CC(C#N)=CC=C2)=NN1CC3=CC(C4=NC=C(C=N4)OCC5CCN(CC5)CCCCCC(NCC67C[C@@H](C[C@@H](C7)C8)C[C@@H]8C6)=O)=CC=C3
Molecular Formula
C45H53N7O3
Molecular Weight
739.95
References & Citations
[1]Min W, et al. Discovery of Potent and Selective c-Met Degraders for Hepatocellular Carcinoma Treatment. J Med Chem. 2024 Jul 4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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