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Sterigmatocystine-13C18

Sterigmatocystine-13C18 is 13C labeled Sterigmatocystine. Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor[1][2]. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals[3].

Product Specifications

UNSPSC

12352005

Target

Antibiotic; Apoptosis; Bacterial; DNA/RNA Synthesis; Endogenous Metabolite; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sterigmatocystine-13c18.html

Concentration

73.06 μM * 1.2 mL in Acetonitrile

Solubility

10 mM in DMSO

Smiles

O=[13C]1[13C]2=[13C](O[13C]3=[13C]1[13C](O)=[13CH][13CH]=[13CH]3)[13C]4=[13C](O[13C@]5([H])[13C@@]4([H])[13CH]=[13CH]O5)[13CH]=[13C]2O[13CH3]

Molecular Formula

13C18H12O6

Molecular Weight

342.15

References & Citations

[1]Kusunoki M, et al. Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbils. Environ Health Prev Med. 2011 Jul;16 (4) :224-31.|[2]Tong YF, et al. Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Facilitates the Development of CardiacHypertroph. Cell Physiol Biochem. 2017;42 (4) :1645-1656.|[3]Schroeder HW, et al. Production of sterigmatocystin by some species of the genus Aspergillus and its toxicity to chicken embryos. Appl Microbiol. 1975 Oct;30 (4) :589-91.|[4]Zhang D, et al. Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells in vitro. PLoS One. 2013 May 21;8 (5) :e65044.|[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.

Shipping Conditions

Room temperature

Scientific Category

Isotope-Labeled Compounds

Clinical Information

No Development Reported

Frequently Asked Questions

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