What is the catalog number for NKP608?

The catalog number for NKP608 is HY-18006.

What sizes are available for NKP608?

NKP608 is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 25 mg, 100 mg.

How many pack sizes does NKP608 come in?

NKP608 is available in 5 different pack sizes.

NKP608 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures NKP608?

NKP608 is manufactured by QuantiMol.

What is the estimated delivery time for NKP608?

Estimated delivery time for NKP608 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for NKP608?

The safety data sheet for NKP608 is available here: http://file.medchemexpress.com/batch_PDF/HY-18006/NKP608-SDS-MedChemExpress.pdf.

NKP608

NKP608 is a non-peptidic derivative of 4-aminopiperidine which acts as a selective, specific and potent antagonist at the neurokinin-1 (NK-1) receptor both in vitro (IC50=2.6 nM) and in vivo. IC50 value: 2.6 nM Target: NK-1 receptor In vitro, the binding of NKP608 to bovine retina was characterized by an IC50 of 2.6+/-0.4 nM, whereas the compound's affinity to other receptor binding sites, including NK-2 and NK-3, was much lower. Species differences in IC (50) values with NKP608 were less pronounced than with previously described NK-1 receptor antagonists, being 13+/-2 and 27+/-2 nM in gerbil midbrain and rat striatum, respectively. In vivo, using the hind foot thumping model in gerbils, NKP608 exhibited a potent NK-1 antagonistic activity following oral administration (ID (50) =0.23 mg/kg; 2 h pretreatment), supporting a central activity of NKP608. NKP608 may prove a useful anxiolytic compound.

Product Specifications

CAS Number

177707-12-9

UNSPSC

12352005

Target

Neurokinin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/NKP608.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=NC2=CC=CC=C12)N[C@@H]3C[C@@H](CC4=CC=C(Cl)C=C4)N(C(C5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5)=O)CC3

Molecular Formula

C31H24ClF6N3O2

Molecular Weight

619.98

References & Citations

[1]El-Hashim AZ, Wyss D, Lewis C. Effect of a novel NK1 receptor selective antagonist (NKP608) on citric acid induced cough and airway obstruction. Pulm Pharmacol Ther. 2004;17 (1) :11-8.|[2]Vendruscolo LF, Takahashi RN, Brüske GR, Ramos A. Evaluation of the anxiolytic-like effect of NKP608, a NK1-receptor antagonist, in two rat strains that differ in anxiety-related behaviors. Psychopharmacology (Berl) . 2003 Nov;170 (3) :287-93.|[3]Rupniak NM, Carlson EJ, Shepheard S, et al. Comparison of the functional blockade of rat substance P (NK1) receptors by GR205171, RP67580, SR140333 and NKP-608. Neuropharmacology. 2003 Aug;45 (2) :231-41.|[4]Gentsch C, Cutler M, Vassout A, et al. Anxiolytic effect of NKP608, a NK1-receptor antagonist, in the social investigation test in gerbils. Behav Brain Res. 2002 Jul 18;133 (2) :363-8.|[5]Vassout A, Veenstra S, Hauser K, et al. NKP608: a selective NK-1 receptor antagonist with anxiolytic-like effects in the social interaction and social exploration test in rats. Regul Pept. 2000 Dec 22;96 (1-2) :7-16.