Hydroxyzine (dihydrochloride)

Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder[1][2].

Product Specifications

CAS Number

[2192-20-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Hydroxyzine-dihydrochloride.html

Purity

99.81

Solubility

H2O : ≥ 150 mg/mL

Smiles

ClC1=CC=C(C=C1)C(C2=CC=CC=C2)N3CCN(CCOCCO)CC3.Cl.Cl

Molecular Formula

C21H29Cl3N2O2

Molecular Weight

447.83

Precautions

H302, H315, H319, H335

References & Citations

[1]Minogiannis, P., et al., Hydroxyzine inhibits neurogenic bladder mast cell activation. Int J Immunopharmacol, 1998. 20 (10) : p. 553-63.|[2]Morichi, R. and G. Pepeu, A study of the influence of hydroxyzine and diazepam on morphine antinociceptoion in the rat. Pain, 1979. 7 (2) : p. 173-80.|[3]Nikita Shekhar Sawantdesai, et al. Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice. J Basic Clin Pharm. 2016 Sep;7 (4) :97-104.