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FKBP12 PROTAC dTAG-13

Product Specifications

UNSPSC Description

FKBP12 PROTAC dTAG-13 (dTAG-13), a PROTAC-based heterobifunctional degrader, is a selective degrader of FKBP12F36V with expression of FKBP12F36V in-frame with a protein of interest. FKBP12 PROTAC dTAG-13 effectively engages FKBP12F36V and CRBN, thereby selectively degrading FKBP12F36V[1].

Target Antigen

FKBP; PROTACs

Type

Reference compound

Related Pathways

Apoptosis;Autophagy;Cell Cycle/DNA Damage;Immunology/Inflammation;PROTAC

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fkbp12-protac-dtag-13.html

Purity

99.75

Solubility

DMSO : ≥ 100 mg/mL

Smiles

COC1=CC=C(CC[C@H](C2=C(OCC(NCCCCCCOC3=CC=CC4=C3C(N(C5CCC(NC5=O)=O)C4=O)=O)=O)C=CC=C2)OC([C@@H]6CCCCN6C([C@@H](CC)C7=CC(OC)=C(OC)C(OC)=C7)=O)=O)C=C1OC

Molecular Weight

1049.17

References & Citations

[1]Nabet B, et al. The dTAG system for immediate and target-specific protein degradation. Nat Chem Biol. 2018 May;14(5):431-441.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-114421/FKBP12-PROTAC-dTAG-13-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-114421/FKBP12-PROTAC-dTAG-13-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

2064175-41-1

Available Sizes

Curated Selection

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