Cardiotrophin-1 (Human, Recombinant)

<strong>Cardiotrophin-1 (Human, Recombinant)</strong>_x000D_ <strong>Catalog number:</strong> B2010349_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Cardiotrophin-1 (Human, Recombinant) expressed in CHO. This protein acts as a member of the IL-6 family of cytokines and a key regulator of energy homeostasis and of glucose and lipid metabolism._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuCT-1; CTF1_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Martínez-Martínez E, Brugnolaro C, Ibarrola J, Ravassa S, Buonafine M, López_x000D_ B, Fernández-Celis A, Querejeta R, Santamaria E, Fernández-Irigoyen J, Rábago G,_x000D_ Moreno MU, Jaisser F, Díez J, González A, López-Andrés N. CT-1_x000D_ (Cardiotrophin-1)-Gal-3 (Galectin-3) Axis in Cardiac Fibrosis and Inflammation._x000D_ Hypertension. 2019 Mar;73(3):602-611._x000D_ _x000D_ 2: Escoté X, Gómez-Zorita S, López-Yoldi M, Milton-Laskibar I, Fernández-_x000D_ Quintela A, Martínez JA, Moreno-Aliaga MJ, Portillo MP. Role of Omentin, Vaspin,_x000D_ Cardiotrophin-1, TWEAK and NOV/CCN3 in Obesity and Diabetes Development. Int J_x000D_ Mol Sci. 2017 Aug 15;18(8):1770._x000D_ _x000D_ 3: Miteva K, Baptista D, Montecucco F, Asrih M, Burger F, Roth A, Fraga-Silva_x000D_ RA, Stergiopulos N, Mach F, Brandt KJ. Cardiotrophin-1 Deficiency Abrogates_x000D_ Atherosclerosis Progression. Sci Rep. 2020 Apr 1;10(1):5791._x000D_ _x000D_ 4: López-Yoldi M, Moreno-Aliaga MJ, Bustos M. Cardiotrophin-1: A multifaceted_x000D_ cytokine. Cytokine Growth Factor Rev. 2015 Oct;26(5):523-32._x000D_ _x000D_ 5: Perretta-Tejedor N, Muñoz-Félix JM, Düwel A, Quiros-Luis Y, Fernández-Martín_x000D_ JL, Morales AI, López-Hernández FJ, López-Novoa JM, Martínez-Salgado C._x000D_ Cardiotrophin_1 opposes renal fibrosis in mice: Potential prevention of chronic_x000D_ kidney disease. Acta Physiol (Oxf). 2019 Jun;226(2):e13247._x000D_ _x000D_ 6: Prieto-Vicente V, Sánchez-Garrido AI, Blanco-Gozalo V, Arévalo M, García-_x000D_ Sánchez E, López-Montañés D, Quiros Y, López-Hernández FJ, Rodríguez-Pérez A,_x000D_ López-Novoa JM. Cardiotrophin-1 attenuates experimental colitis in mice. Clin_x000D_ Sci (Lond). 2018 May 23;132(9):985-1001._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/30892966/">7: Carneros D, Santamaría EM, Larequi E, Vélez-Ortiz JM, Reboredo M, Mancheño U,_x000D_ Perugorria MJ, Navas P, Romero-Gómez M, Prieto J, Hervás-Stubbs S, Bustos M._x000D_ Cardiotrophin-1 is an anti-inflammatory cytokine and promotes IL-4-induced M2_x000D_ macrophage polarization. FASEB J. 2019 Jun;33(6):7578-7587. </a>_x000D_ _x000D_ <strong>Products Related to Cardiotrophin-1 (Human, Recombinant) </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>