Tubulin polymerization-IN-43
Product Specifications
UNSPSC Description
Tubulin polymerization-IN-43 (compound 15h) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-43 disrupts cellular microtubule networks by targeting the Colchicine (HY-16569) site, and promots cell cycle arrest of leukemia cells at G2/M phase and cell apoptosis, as well as inhibiting angiogenesis[1].
Target Antigen
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tubulin-polymerization-in-43.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC1=CC2=C(N=C(C(F)(F)F)N=C2N(C)C3=CC=C(OC)C=C3)C=C1
Molecular Weight
351.30
References & Citations
[1]Wu H, et, al. Discovery of novel N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as the inhibitors of tubulin polymerization in leukemia cells. Eur J Med Chem. 2023 Aug 5;256:115470.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-149363/Tubulin-polymerization-IN-43-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-149363/Tubulin-polymerization-IN-43-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2773345-90-5
Available Sizes
Curated Selection
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