Tubulin polymerization-IN-43

Tubulin polymerization-IN-43 (compound 15h) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-43 disrupts cellular microtubule networks by targeting the Colchicine (HY-16569) site, and promots cell cycle arrest of leukemia cells at G2/M phase and cell apoptosis, as well as inhibiting angiogenesis[1].

Product Specifications

CAS Number

[2773345-90-5]

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-polymerization-in-43.html

Purity

99.60

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC1=CC2=C(N=C(C(F)(F)F)N=C2N(C)C3=CC=C(OC)C=C3)C=C1

Molecular Formula

C17H13F4N3O

Molecular Weight

351.30

References & Citations

[1]Wu H, et, al. Discovery of novel N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives as the inhibitors of tubulin polymerization in leukemia cells. Eur J Med Chem. 2023 Aug 5;256:115470.