BMS-986397

BMS-986397 is a cereblon-based CK1α (casein kinase 1α) molecular glue degrader that can cause rapid apoptosis and cell cycle arrest in TP53 wild-type AML (acute myeloid leukemia) cells. BMS-986397 can be used for the study of AML and HR-MDS (High-Risk Myelodysplastic Syndrome) [1].

Product Specifications

CAS Number

[2564486-44-6]

UNSPSC

12352005

Target

Apoptosis; Casein Kinase; Ligands for E3 Ligase; Molecular Glues

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; PROTAC; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bms-986397.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1CC[C@@H](C(N1)=O)N2CC3=C(C2=O)C=CC(C(N[C@@H](C(F)(F)F)C4=NC=CC=C4Cl)=O)=C3

Molecular Formula

C21H16ClF3N4O4

Molecular Weight

480.82

References & Citations

[1]Carmen Jimenez, et al. BMS-986397, a First-in-Class Molecular Glue Degrader of Casein Kinase 1α (CK1α) for the Treatment of Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (HR-MDS) Harboring Functional TP53. Blood. Volume 144, Supplement 1, 5 November 2024, Page 4142.