G7-18NATE (TFA)
Product Specifications
UNSPSC Description
G7-18NATE TFA is a peptide inhibitor of Grb7. G7-18NATE TFA binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM). G7-18NATE TFA inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines[1][2].
Target Antigen
Others
Type
Peptides
Related Pathways
Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/g7-18nate-tfa.html
Purity
98.59
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC(C(F)(F)F)=O.O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC3=CC=CC=C3)C(N4[C@@H](CCC4)C(N[C@@H](CSC5)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC6=CNC7=CC=CC=C67)NC5=O.[x]
Molecular Weight
1417.50 (free base)
References & Citations
[1]Sang J, et al. Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity. Molecules. 2019 Oct 17;24(20):3739.|[2]Giricz O, et al. GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Res Treat. 2012 Jun;133(2):607-15.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P10224A/G7-18NATE-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P10224A/G7-18NATE-TFA-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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