G7-18NATE (TFA)

G7-18NATE TFA is a peptide inhibitor of Grb7. G7-18NATE TFA binds to the Grb7-SH2 domain with micromolar affinity (Kd = 18.1 μM) . G7-18NATE TFA inhibits cell proliferation, motility, cell invasion and 3D culture formation in several cancer cell lines[1][2].

Product Specifications

UNSPSC

12352209

Target

EGFR

Type

Peptides

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/g7-18nate-tfa.html

Purity

98.06

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(C(F)(F)F)=O.O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCC(O)=O)C(NCC(N[C@@H](CC2=CC=C(C=C2)O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(N)=O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC3=CC=CC=C3)C(N4[C@@H](CCC4)C(N[C@@H](CSC5)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC6=CNC7=CC=CC=C67)NC5=O.[x]

Molecular Formula

C67H80N14O19S.xC2HF3O2

Molecular Weight

1417.50 (free base)

References & Citations

[1]Sang J, et al. Evaluation of Cyclic Peptide Inhibitors of the Grb7 Breast Cancer Target: Small Change in Cargo Results in Large Change in Cellular Activity. Molecules. 2019 Oct 17;24 (20) :3739.|[2]Giricz O, et al. GRB7 is required for triple-negative breast cancer cell invasion and survival. Breast Cancer Res Treat. 2012 Jun;133 (2) :607-15.