Harringtonolide

Harringtonolide is a potent RACK1 inhibitor (IC50=39.66 μM in A375 cells) . Harringtonolide inhibits the epithelial-mesenchymal transition (EMT) process and cell proliferation by affecting the interaction between FAK and RACK1. Harringtonolide has plant growth inhibitory, antiviral, anti-inflammatory, and antiproliferation activities[1].

Product Specifications

CAS Number

[64761-48-4]

UNSPSC

12352005

Target

FAK

Type

Natural Products

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/harringtonolide.html

Purity

98.0

Solubility

DMSO : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1C=C(CC2)C3=C([C@H]4C(C5O6)C3[C@@]2([C@H](C)[C@H]5O4)C6=O)C(C)=C1

Molecular Formula

C19H18O4

Molecular Weight

310.34

References & Citations

[1]Zhu TY, et al. Photoaffinity Probe Reveals the Potential Target of Harringtonolide for Cancer Cell Migration Inhibition. ACS Med Chem Lett. 2022;13 (3) :449-456. Published 2022 Feb 2.