HIV-1 inhibitor-8

HIV-1 inhibitor-8 is an orally active, low-toxicity and potent HIV 1 non-nucleoside reverse transcriptase inhibitor (NNRTI) . HIV-1 inhibitor-8 yields exceptionally potent antiviral activities (EC50=4.44~54.5 nM) against various HIV 1 strains. The IC50 of HIV-1 inhibitor-8 against WT HIV-1 reverse transcriptase is 0.081 μM[1].

Product Specifications

CAS Number

[2826996-78-3]

UNSPSC

12352005

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/hiv-1-inhibitor-8.html

Purity

98.03

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

N#CC1=CC=C(NC2=NC(OC3=C(C)C=C(/C=C/C#N)C=C3C)=C(CSCC4)C4=N2)C=C1

Molecular Formula

C25H21N5OS

Molecular Weight

439.53

References & Citations

[1]Wang Z, et al. Discovery of Novel Dihydrothiopyrano[4,3-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles [published online ahead of print, 2021 Aug 25]. J Med Chem. 2021;10.1021/acs.jmedchem.1c01015.