Lycorine (hydrochloride)

Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (L’Her.) Herb. and is also a melanoma vasculogenic inhibitor and has anti-tumor activity[1]. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC50 of 1.2 μM) [2].

Product Specifications

CAS Number

[2188-68-3]

UNSPSC

12352005

Hazard Statement

H301

Target

Autophagy; Bacterial; Virus Protease

Type

Natural Products

Related Pathways

Anti-infection; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Lycorine-hydrochloride.html

Purity

99.89

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@@H](O)C=C(CC2)[C@@]3([H])N2CC4=C([C@@]31[H])C=C(OCO5)C5=C4.Cl

Molecular Formula

C16H18ClNO4

Molecular Weight

323.77

Precautions

H301

References & Citations

[1]Liu, R. et al. Lycorine hydrochloride inhibits metastatic melanoma cell-dominant vasculogenic mimicry. Pigment cell & melanoma research 25, 630-638, doi:10.1111/j.1755-148X.2012.01036.x (2012) .|[2]Cao, Z. et al.Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity. Toxicology letters 218, 174-185, doi:10.1016/j.toxlet.2013.01.018 (2013) .