N-Desmethyl Galanthamine

N-Desmethyl Galanthamine (N-Norgalanthamine) is a metabolite of Galanthamine (HY-76299) . N-Desmethyl Galanthamine is an EeAChE inhibitor with an IC50 of 2.76 μM. N-Desmethyl Galanthamine can be used in the research of Alzheimer's disease[1][2][3].

Product Specifications

CAS Number

[41303-74-6]

Product Name Alternative

Norgalanthamine

UNSPSC

12352005

Hazard Statement

H300

Target

Cholinesterase (ChE) ; Drug Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/n-desmethyl-galanthamine.html

Purity

99.60

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O[C@H]1C=C[C@@]23CCNCC4=CC=C(OC)C(O[C@@]3([H])C1)=C24

Molecular Formula

C16H19NO3

Molecular Weight

273.33

Precautions

H300

References & Citations

[1]Melanie-Jayne R. Howes, et al. Acetylcholinesterase inhibitors of natural origin. International Journal of Research in Pharmaceutical and Biomedical Sciences 3 (SI 1) :67-86.|[2]Bachus R, et al. The O-demethylation of the antidementia drug galanthamine is catalysed by cytochrome P450 2D6. Pharmacogenetics. 1999;9 (6) :661-668.|[3]Cahlíková L, et al. Recent Progress on Biological Activity of Amaryllidaceae and Further Isoquinoline Alkaloids in Connection with Alzheimer's Disease. Molecules. 2021 Aug 29;26 (17) :5240.