Elzovantinib
Elzovantinib (TPX-0022) is an oral-active inhibitor of SRC, MET and c-FMS, with IC50 values of 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively[1].
Product Specifications
CAS Number
[2271119-26-5]
Product Name Alternative
TPX-0022; CSF1R-IN-2
UNSPSC
12352005
Target
C-Fms; c-Met/HGFR; Src
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/elzovantinib.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
N#CC1=C2CN(CC)C(C=C3)=NC(N3N=C4N)=C4C(NC[C@H](C)OC2=CC=C1F)=O
Molecular Formula
C20H20FN7O2
Molecular Weight
409.42
References & Citations
[1]WO 2019023417 A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Curated Selection
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