Hydralazine (hydrochloride)

Hydralazine hydrochloride is an antihypertensive agent. Hydralazine hydrochloride can inhibit mitochondrial fission and human peritoneal mesothelial cell proliferation. Hydralazine hydrochloride has immunomodulation and anti-migratory effect. Hydralazine hydrochloride activates the intrinsic pathway of apoptosis and causes DNA damage[1][2][3][4][5].

Product Specifications

CAS Number

[304-20-1]

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

Apoptosis; Bcl-2 Family; Caspase

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Hydralazine-hydrochloride.html

Purity

99.97

Solubility

H2O : 25 mg/mL (ultrasonic)

Smiles

NNC1=NN=CC2=C1C=CC=C2.Cl

Molecular Formula

C8H9ClN4

Molecular Weight

196.64

Precautions

H301, H315, H319, H335

References & Citations

[1]Fang C C, et al. Hydralazine inhibits human peritoneal mesothelial cell proliferation and collagen synthesis [J]. Nephrology Dialysis Transplantation, 1996, 11 (11) : 2276-2281.|[2]Kalkhoran S B, et al. Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission [J]. Cardiovascular Research, 2022, 118 (1) : 282-294.|[3]Ruiz-Magaña M J, et al. The antihypertensive drug hydralazine activates the intrinsic pathway of apoptosis and causes DNA damage in leukemic T cells [J]. Oncotarget, 2016, 7 (16) : 21875.|[4]Quan X, et al. Hydralazine plays an immunomodulation role of pro-regeneration in a mouse model of spinal cord injury [J]. Experimental Neurology, 2023, 363: 114367.|[5]Rodrigues S F, et al. Hydralazine reduces leukocyte migration through different mechanisms in spontaneously hypertensive and normotensive rats [J]. European journal of pharmacology, 2008, 589 (1-3) : 206-214.