Nicotelline

Nicotelline (Nicotellin) is a nicotine-related alkaloid, as well as a weak inhibitor of human cDNA-expressed cytochrome P-450 2A6 (CYP2A6) . CYP2A6 mediates coumarin 7-hydroxylation, while Nicotelline fails to exhibit inhibition at 300 μM. Nicotelline can be used as a tracer and biomarker of particulate matter (PM) derived from tobacco smoke[1][2].

Product Specifications

CAS Number

[494-04-2]

Product Name Alternative

Nicotellin

UNSPSC

12352005

Target

Cytochrome P450

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nicotelline.html

Concentration

10mM

Purity

98.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C1(C2=CC=NC(C3=CN=CC=C3)=C2)=CN=CC=C1

Molecular Formula

C15H11N3

Molecular Weight

233.27

References & Citations

[1]Denton TT, et al. Nicotine-related alkaloids and metabolites as inhibitors of human cytochrome P-450 2A6. Biochem Pharmacol. 2004 Feb 15;67 (4) :751-6. |[2]Jacob P 3rd, et al. Nicotelline: a proposed biomarker and environmental tracer for particulate matter derived from tobacco smoke. Chem Res Toxicol. 2013 Nov 18;26 (11) :1615-31.