(14S,15R) -14-Deoxyoxacyclododecindione
(14S,15R) -14-Deoxyoxacyclododecindione (Compound 3) is an inhibitor for TGF-β-dependent Smad2/3 and IL-4-dependent STAT6 signaling pathway, with IC50s of 90 and 20 nM, respectively[1][2].
Product Specifications
CAS Number
1899061-36-9
UNSPSC
12352005
Target
Interleukin Related; STAT; TGF-beta/Smad
Type
Reference compound
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/smad2-3-in-2.html
Solubility
10 mM in DMSO
Smiles
OC1=C(C(/C(C)=C/CC[C@H](C)[C@@H](C)OC2=O)=O)C(C2)=C(Cl)C(O)=C1
Molecular Formula
C18H21ClO5
Molecular Weight
352.81
References & Citations
[1]Seipp K, et al., Total Synthesis, Structure Reassignment, and Biological Evaluation of the Anti-Inflammatory Macrolactone 13-Hydroxy-14-deoxyoxacyclododecindione. J Nat Prod. 2024 Mar 31.|[2]Johannes Tauber, et al. A surprising switch in absolute configuration of anti-inflammatory macrolactones. Org Biomol Chem. 2016 Apr 12;14 (15) :3695-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-4
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