ARN19702
ARN19702 is a selective, orally active, reversible, and brain-penetrant N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 230 nM for human NAAA. ARN19702 has pain relief effects[1][2].
Product Specifications
CAS Number
1971937-18-4
UNSPSC
12352005
Target
Ceramidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/arn19702.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@H]1CN(CCN1C(C2=C(C=CC=C2)S(CC)(=O)=O)=O)C(SC3=C4)=NC3=CC=C4F
Molecular Formula
C21H22FN3O3S2
Molecular Weight
447.55
References & Citations
[1]Yannick Fotio, et al. Antinociceptive Profile of ARN19702, (2-Ethylsulfonylphenyl) -[ (2S) -4- (6-fluoro-1,3-benzothiazol-2-yl) -2-methylpiperazin-1-yl]methanone, a Novel Orally Active N-Acylethanolamine Acid Amidase Inhibitor, in Animal Models. J Pharmacol Exp Ther. 2021 Aug;378 (2) :70-76.|[2]Marco Migliore Dr, et al. Second-Generation Non-Covalent NAAA Inhibitors are Protective in a Model of Multiple Sclerosis. Angew Chem Int Ed Engl. 2016 Sep 5;55 (37) :11193-11197.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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