NH2-PEG2-C2-Boc
NH2-PEG2-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG2-C2-Boc is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [2].
Product Specifications
CAS Number
[756525-95-8]
UNSPSC
12352203
Hazard Statement
H302
Target
ADC Linker; PROTAC Linkers
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nh2-peg2-c2-boc.html
Purity
99.62
Solubility
DMSO : ≥ 100 mg/mL
Smiles
NCCOCCOCCC(OC(C)(C)C)=O
Molecular Formula
C11H23NO4
Molecular Weight
233.30
Precautions
H302
References & Citations
[1]Han X, et al. Discovery of ARD-69 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor (AR) for the Treatment of Prostate Cancer. J Med Chem. 2019 Jan 24;62 (2) :941-964.|[2]Joshua D. Thomas, et al. Pyrrolobenzodiazepine antibody conjugates. WO2019126691A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Alkyl/ether Linkers; Non-cleavable Linker; PEG Linkers
Available Sizes
Curated Selection
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