Z-LLNle-CHO
Product Specifications
Product Name Alternative
Z-Leu-Leu-Nle-CHO; GSII
UNSPSC Description
Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia[1][2].
Target Antigen
Apoptosis; Proteasome; γ-secretase
Type
Peptides
Related Pathways
Apoptosis;Metabolic Enzyme/Protease;Neuronal Signaling;Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z-llnle-cho.html
Purity
97.61
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)N[C@@H](CC(C)C)C(N[C@H](C=O)CCCC)=O
Molecular Weight
475.62
References & Citations
[1]Han J, et al. The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition. Breast Cancer Res. 2009;11(4):R57. |[2]Meng X, et al. GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia. Leukemia. 2011 Jul;25(7):1135-46.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-120234/Z-LLNle-CHO-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-120234/Z-LLNle-CHO-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
133407-83-7
Available Sizes
Curated Selection
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