Z-LLNle-CHO

Z-LLNle-CHO (Z-Leu-Leu-Nle-CHO) is a γ-secretase inhibitor I. Z-LLNle-CHO induces caspase and ROS-dependent apoptosis by blocking the Akt-mediated pro-survival pathway. Z-LLNle-CHO can be used in cancer research, such as breast cancer and leukaemia[1][2].

Product Specifications

CAS Number

[133407-83-7]

Product Name Alternative

Z-Leu-Leu-Nle-CHO; GSII

UNSPSC

12352209

Hazard Statement

H302, H315, H319

Target

Apoptosis; Proteasome; γ-secretase

Type

Peptides

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z-llnle-cho.html

Purity

97.18

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H](CC(C)C)NC(OCC1=CC=CC=C1)=O)N[C@@H](CC(C)C)C(N[C@H](C=O)CCCC)=O

Molecular Formula

C26H41N3O5

Molecular Weight

475.62

Precautions

H302, H315, H319

References & Citations

[1]Han J, et al. The cytotoxicity of gamma-secretase inhibitor I to breast cancer cells is mediated by proteasome inhibition, not by gamma-secretase inhibition. Breast Cancer Res. 2009;11 (4) :R57. |[2]Meng X, et al. GSI-I (Z-LLNle-CHO) inhibits γ-secretase and the proteosome to trigger cell death in precursor-B acute lymphoblastic leukemia. Leukemia. 2011 Jul;25 (7) :1135-46.