NVP-BAW2881

NVP-BAW2881 (BAW2881) is a potent and selective VEGFR2 inhibitor with an IC50 of 9 nM[1][2].

Product Specifications

CAS Number

[861875-60-7]

Product Name Alternative

BAW2881

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Tie; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/NVP-BAW2881.html

Purity

98.54

Solubility

DMSO : 31.25 mg/mL (ultrasonic)

Smiles

O=C(C1=C2C=CC(OC3=NC(N)=NC=C3)=CC2=CC=C1)NC4=CC=CC(C(F)(F)F)=C4

Molecular Formula

C22H15F3N4O2

Molecular Weight

424.38

Precautions

H302, H315, H319, H335

References & Citations

[1]Bold G, et al. A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis. J Med Chem. 2016 Jan 14;59 (1) :132-46.|[2]Halin C, et al. Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor. Am J Pathol. 2008 Jul;173 (1) :265-77.