NVP-BAW2881
NVP-BAW2881 (BAW2881) is a potent and selective VEGFR2 inhibitor with an IC50 of 9 nM[1][2].
Product Specifications
CAS Number
861875-60-7
Product Name Alternative
BAW2881
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Tie; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Endocrinology; Cancer
Assay Protocol
https://www.medchemexpress.com/NVP-BAW2881.html
Purity
98.54
Solubility
DMSO : 31.25 mg/mL (ultrasonic)
Smiles
O=C(C1=C2C=CC(OC3=NC(N)=NC=C3)=CC2=CC=C1)NC4=CC=CC(C(F)(F)F)=C4
Molecular Formula
C22H15F3N4O2
Molecular Weight
424.38
Precautions
H302, H315, H319, H335
References & Citations
[1]Bold G, et al. A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis. J Med Chem. 2016 Jan 14;59 (1) :132-46.|[2]Halin C, et al. Inhibition of chronic and acute skin inflammation by treatment with a vascular endothelial growth factor receptor tyrosine kinase inhibitor. Am J Pathol. 2008 Jul;173 (1) :265-77.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Tie2; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4
Available Sizes
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