ERα degrader 10
ERα degrader 10 is a selective and orally active estrogen receptor α (ERα) degrader. ERα degrader 10 exhibits potent ERα binding affinity (IC50 of 24.0 nM) and degradation ability (EC50 of 5.3 nM) . ERα degrader 10 degrades ERα through the proteasome-mediated pathway. ERα degrader 10 can be used for the study of breast cancer[1].
Product Specifications
UNSPSC
12352005
Target
Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/erα-degrader-10.html
Smiles
O=C(O)/C=C/C1=CC=C(/C(C2=CC=C(C3=CN(C)N=C3)C=C2)=C(C4=CC=CC=C4Cl)/CC)C=C1
Molecular Formula
C29H25ClN2O2
Molecular Weight
468.97
References & Citations
[1]Rupeng Dai, et al. Drug discovery of N-methyl-pyrazole derivatives as potent selective estrogen receptor degrader (SERD) for the treatment of breast cancer. Eur J Med Chem. 2024 Sep 23:279:116894.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα
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