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GPR52 antagonist-1

GPR52 antagonist-1 (Compound 43) is a GPR52 antagonist with an IC50 of 0.63 μM. GPR52 antagonist-1 reduces mHTT (mutant huntingtin protein) levels by targeting GPR52 and promotes survival of mouse primary striatal neurons[1].

Product Specifications

CAS Number

1239987-91-7

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

GPR52

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gpr52-antagonist-1.html

Purity

99.80

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CS1)/C=C/CCC2=CC=CC=C2

Molecular Formula

C15H14OS

Molecular Weight

242.34

Precautions

H302, H315, H319

References & Citations

[1]Wang C, et al. GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes. J Med Chem. 2021 Jan 28;64 (2) :941-957.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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