GPR52 antagonist-1
GPR52 antagonist-1 (Compound 43) is a GPR52 antagonist with an IC50 of 0.63 μM. GPR52 antagonist-1 reduces mHTT (mutant huntingtin protein) levels by targeting GPR52 and promotes survival of mouse primary striatal neurons[1].
Product Specifications
CAS Number
[1239987-91-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
GPR52
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gpr52-antagonist-1.html
Purity
99.80
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CS1)/C=C/CCC2=CC=CC=C2
Molecular Formula
C15H14OS
Molecular Weight
242.34
Precautions
H302, H315, H319
References & Citations
[1]Wang C, et al. GPR52 Antagonist Reduces Huntingtin Levels and Ameliorates Huntington's Disease-Related Phenotypes. J Med Chem. 2021 Jan 28;64 (2) :941-957.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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