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SB251023

SB251023 is a β3-adrenergic receptor agonist with pEC50 values of 7.14 and 6.91 for the β3a- and β3b-adrenergic receptors, respectively. SB251023 is capable of modulating cyclic AMP levels and extracellular acidification rate (EAR) in cells. It has potential application value in the study of cardiovascular diseases and metabolic-related disorders[1].

Product Specifications

CAS Number

[208842-53-9]

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/sb251023.html

Smiles

O=P(COC1=CC=C(C=C1)CC2(CCCC2)NC[C@@H](COC3=CC=C(C=C3)O)O)(O)C4=CC=CC=C4

Molecular Formula

C28H34NO6P

Molecular Weight

511.55

References & Citations

[1]Hutchinson D S, et al. Mouse β3a‐and β3b‐adrenoceptors expressed in Chinese hamster ovary cells display identical pharmacology but utilize distinct signalling pathways[J]. British journal of pharmacology, 2002, 135 (8) : 1903-1914.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

β adrenergic receptor

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