(S) -Flurbiprofen
(S) -Flurbiprofen is an active enantiomer of Flurbiprofen, with IC50 values of 0.48 μM and 0.47 μM for COX-1 and COX-2, respectively[1].
Product Specifications
CAS Number
51543-39-6
Product Name Alternative
Esflurbiprofen
UNSPSC
12352005
Hazard Statement
H301
Target
COX; PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/s-flurbiprofen.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)[C@@H](C)C1=CC=C(C2=CC=CC=C2)C(F)=C1
Molecular Formula
C15H13FO2
Molecular Weight
244.26
Precautions
H301
References & Citations
[1]A Carabaza, et al. Stereoselective Inhibition of Inducible Cyclooxygenase by Chiral Nonsteroidal Antiinflammatory Drugs. J Clin Pharmacol. 1996 Jun;36 (6) :505-12.|[2]B Averbeck, et al. Inflammatory Mediators Do Not Stimulate CGRP Release if Prostaglandin Synthesis Is Blocked by S (+) -flurbiprofen in Isolated Rat Skin. Inflamm Res. 2003 Dec;52 (12) :519-23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
COX-1; COX-2
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