AZ7550 Mesylate

AZ7550 Mesylate is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.

Product Specifications

CAS Number

[2319837-99-3]

Product Name Alternative

AZ7550 trimesylate salt

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Metabolite; EGFR; IGF-1R

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/AZ7550_Mesylate.html

Purity

98.70

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

CN1C=C(C2=NC(NC3=CC(NC(C=C)=O)=C(N(CCNC)C)C=C3OC)=NC=C2)C4=CC=CC=C41.O=S(O)(C)=O.O=S(O)(C)=O.O=S(O)(C)=O

Molecular Formula

C30H43N7O11S3

Molecular Weight

773.90

Precautions

H302, H315, H319, H335

References & Citations

[1]Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57 (20) :8249-67.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Citation 01

BioRxiv. 2024 Jul 2:2024.06.27.600680.|Patent. US20250275968A1.|Biopharm Drug Dispos. 2023 Apr;44 (2) :165-174.|J Pharm Biomed Anal. 2025 Jan 3:255:116662.