AZ7550 Mesylate
AZ7550 Mesylate is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.
Product Specifications
CAS Number
2319837-99-3
Product Name Alternative
AZ7550 trimesylate salt
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite; EGFR; IGF-1R
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/AZ7550_Mesylate.html
Purity
98.70
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CN1C=C(C2=NC(NC3=CC(NC(C=C)=O)=C(N(CCNC)C)C=C3OC)=NC=C2)C4=CC=CC=C41.O=S(O)(C)=O.O=S(O)(C)=O.O=S(O)(C)=O
Molecular Formula
C30H43N7O11S3
Molecular Weight
773.90
Precautions
H302, H315, H319, H335
References & Citations
[1]Finlay MR, et al. Discovery of a potent and selective EGFR inhibitor (AZD9291) of both sensitizing and T790M resistance mutations that spares the wild type form of the receptor. J Med Chem. 2014 Oct 23;57 (20) :8249-67.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Citation 01
BioRxiv. 2024 Jul 2:2024.06.27.600680.|Patent. US20250275968A1.|Biopharm Drug Dispos. 2023 Apr;44 (2) :165-174.|J Pharm Biomed Anal. 2025 Jan 3:255:116662.
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