Desonide

Desonide is a non-fluorinated corticosteroid anti-inflammatory agent that acts on the glucocorticoid receptor. Desonide can also specifically bind to the mutant huntingtin protein (mHTT), reducing the level and toxicity of mHTT. Desonide can be used in the research of Huntington's disease and inflammatory diseases such as atopic dermatitis[1][2][3][4].

Product Specifications

CAS Number

[638-94-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Glucocorticoid Receptor; Huntingtin

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Neuronal Signaling; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/desonide.html

Purity

99.64

Solubility

DMSO : ≥ 100 mg/mL

Smiles

C[C@@]12[C@@]3(C(CO)=O)[C@@](OC(C)(O3)C)([H])C[C@@]1([H])[C@]4([H])CCC5=CC(C=C[C@]5(C)[C@@]4([H])[C@@H](O)C2)=O

Molecular Formula

C24H32O6

Molecular Weight

416.51

Precautions

H302, H315, H319, H335

References & Citations

[1]Kahanek, N., C. Gelbard, and A. Hebert, Desonide: a review of formulations, efficacy and safety. Expert Opin Investig Drugs, 2008. 17 (7) : p. 1097-104.|[2]Castanedo-Cazares, J.P., et al., Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study. Clin Cosmet Investig Dermatol, 2013. 6: p. 29-36.|[3]Phillips BM, et al. The physical, animal and human pharmacologic, and toxicologic properties of desonide, a new, topically active, antiinflammatory steroid. Toxicol Appl Pharmacol. 1971 Dec;20 (4) :522-37.|[4]Song H, et al. Suppression of toxicity of the mutant huntingtin protein by its interacting compound, desonide. Proc Natl Acad Sci U S A. 2022 Mar 8;119 (10) :e2114303119.