Carvacrol

Carvacrol is an orally active monoterpenic phenol that can be extract from an abundant number of aromatic plants, including thyme and oregano, possessing antioxidant, antibacterial, antifungal, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant properties. Carvacrol also causes cell cycle arrest in G0/G1, downregulates Notch-1, and Jagged-1, and induces apoptosis. Carvacrol is used in low concentrations as a food flavoring ingredient and preservative, as well as a fragrance ingredient in cosmetic formulations[1][2].

Product Specifications

CAS Number

[499-75-2]

Product Name Alternative

Cymophenol

UNSPSC

12352005

Hazard Statement

H302, H314, H411

Target

Apoptosis; Bacterial; Endogenous Metabolite; Fungal; Notch

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/carvacrol.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC(C(C)C)=CC=C1C

Molecular Formula

C10H14O

Molecular Weight

150.22

Precautions

H302, H314, H411

References & Citations

[1]Khan F, et al. Carvacrol Induced Program Cell Death and Cell Cycle Arrest in Androgen-Independent Human Prostate Cancer Cells via Inhibition of Notch Signaling. Anticancer Agents Med Chem. 2019 Jul 31.|[2]Suntres ZE, et al. The bioactivity and toxicological actions of carvacrol. Crit Rev Food Sci Nutr. 2015;55 (3) :304-18.|[3]Kara M, et al. Supplemental carvacrol can reduce the severity of inflammation by influencing the production of mediators of inflammation. Inflammation. 2015;38 (3) :1020-7.