MLKL (phospho Ser358) rabbit pAb
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
Product Specifications
Background
Synonyms
Mixed lineage kinase domain-like protein
Gene ID
197259
UniProt
Q8NB16
Cellular Locus
Host
Rabbit
Species Reactivity
Human
Reactivity
Human
Immunogen
Synthesized peptide derived from human MLKL (phospho S358)
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
IHC, IF, WB
Validated Applications
IHC,IF,WB
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
IHC-p 1:100-500; IF/ICC 1:100-500; WB 1:500-2000
Molecular Weight
55kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES14935-1.pdf
Observed Molecular Weight
55 kD
Subcellular Location
Other Product Names
Mixed lineage kinase domain-like protein
Gene ID (Human)
197259
SwissProt (Human)
Q8NB16
Available Sizes
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