BMS-191011

BMS 191011 (BMS-A) is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel) . BMS-191011 shows neuroprotective activities in rodent models of stroke[1].

Product Specifications

CAS Number

[202821-81-6]

Product Name Alternative

BMS-A

UNSPSC

12352005

Hazard Statement

H301, H413

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bms-191011.html

Purity

99.56

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1OC(C2=CC=C(C(F)(F)F)C=C2)=NN1CC3=CC(Cl)=CC=C3O

Molecular Formula

C16H10ClF3N2O3

Molecular Weight

370.71

Precautions

H301, H413

References & Citations

[1]Romine JL, et al. 3-[ (5-Chloro-2-hydroxyphenyl) methyl]-5-[4- (trifluoromethyl) phenyl ]-1,3,4-oxadiazol-2 (3H) -one, BMS-191011: opener of large-conductance Ca (2+) -activated potassium (maxi-K) channels, identification, solubility, and SAR. J Med Chem. 2007 Feb 8;50 (3) :528-42.|[2]Asami Mori, et al. BMS-191011, an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo. Biol Pharm Bull. 2011;34 (1) :150-2.|[3]Remigante A, et al. NS-11021 Modulates Cancer-Associated Processes Independently of BK Channels in Melanoma and Pancreatic Duct Adenocarcinoma Cell Lines. Cancers (Basel) . 2021 Dec 6;13 (23) :6144.